Biomedical Research - Salmonics LLC

At Salmonics we create high-value research tools so you can innovate. Our foundation lies in fish-derived plasma and serum, which offer similar properties to bovine, human, and other similarly sourced materials, but with a variety of advantages and can be tailored to meet diverse research needs.

Fish-derived products perform equal to or better than other products and include benefits such as being free of mammalian pathogens, enhancing the proliferation of stem cells, and reducing the risk of false positives which means that researchers yield cleaner results they can trust.

Looking for Custom Formulations? We’ve Got You Covered!

We specialize in tailoring solutions to fit your specific application or ELISA kit needs. With a reliable supply chain ensuring fresh serum and plasma, we offer a variety of customizable formulations and volumes. Your unique research and diagnostic kit needs deserve a customizable solution. Let’s discuss your custom formulation needs!

Fish-derived extracellular matrix (ECM) proteins perform as well as, or better than, those from mammalian sources across a variety of cells and applications. Compared with mammalian fibrin, salmon fibrin promotes greater neurite outgrowth, exhibits slower degradation kinetics, and has demonstrated non-toxicity in animal models [4]. Laboratory studies further show that salmon fibronectin enhances cell adhesion and spreading, performing comparably to human fibronectin with fibroblasts, melanoma cells, mouse spinal cord neurons, and human neutrophils (citation or in-house QC). NIH 3T3 mouse embryonic fibroblasts grown on salmon fibronectin–coated matrices displayed growth equivalent to those on human fibronectin (Cruz, pers. comm.), while comparative studies with rCHO cells revealed significantly higher cell densities in salmon fibronectin cultures beginning at day two post-inoculation, reaching more than twice the density of human and bovine fibronectin by day three (Sawyer, pers. comm.).

Additionally, our supply chain remains stable and unaffected by the viruses and supply fluctuations that can affect cattle-derived proteins. This ensures consistent deliverability and pricing, which is a necessity in the fast-moving world of biomedical research.

Salmon Fibrinogen, Thrombin, and Fibronectin

Salmon fibrinogen, thrombin, and fibronectin are the building blocks that create a range of hydrogels and matrices, such as injectable scaffolds and ECM-fibrin hybrids for cell growth and migration in 3D assays. These advanced matrices play a crucial role in cancer research and other biomedical studies. Fish-based hydrogels have been shown to enhance the growth of certain cell types while exhibiting longer stability, a broader temperature range, and cell compatibility stiffness compared to hydrogels derived from other sources. They can be readily prepared through the polymerization of salmon fibrinogen and thrombin, with the inclusion of fibronectin providing early growth benefits. In addition, their elasticity and rigidity can be tuned to meet specific experimental needs.

Salmon fibrin matrices are scientifically proven to stimulate greater stem cell and neurite proliferation, provide support for capillary morphogenesis, enable stem cell selection from bulk preparations without cell sorting, and facilitate the selection of tumorigenic cells.

Mouse spinal cord neurons embedded in salmon, bovine or human fibrin for 3 days were immunostained with TuJ1 or Map5/Map1b antibodies to visualize neurites. Scale bar is 50 µm. The effect of the different matrices on neurite growth was quantified by measuring the total neurite length per cell (⁎⁎p < 0.001 salmon fibrin vs. bovine or human fibrin). Figure 2 (C), page 13.

Ju et al. (2007) Enhanced neurite growth from mammalian neurons in three-dimensional salmon fibrin gels. Biomaterials 28: 2097-2108.

Sea Block® – The Original Fish-Based Blocking Buffer

Salmonics’ story begins with the invention of our legacy product Sea Block® which pioneered using salmon-derived proteins to create a blocking buffer.

Unlike traditional blockers, Sea Block minimizes background noise, enhances signal clarity, and ensures more reliable results in mammalian assays.

Trusted in labs worldwide since the 1980s, Sea Block is a go-to choice for Western Blot, IHC, ELISA, immunoblots, and immunofluorescence assays. Researchers rely on it for cleaner, clearer, and more cost-effective results because they know precision in science starts with the right foundation.

Interested in our biomedical research tools?