Blood clotting proteins derived from Atlantic salmon (Salmo salar)
Fibrinogen starting at $165 USD for 100 mg. Thrombin starting at $98 USD for 250 IU. Contact us for large volume pricing and availability.
Key Advantages
- Enhanced Extracellular Matrix (ECM): More efficient than human-derived fibrin [5]
- Prolonged Hydrogel Stability: Slower degradation in vitro and in vivo
- Optimal Stem Cell Performance: Excellent selection and proliferation of stem cells [6]
- Neuronal Growth Support: Superior for neurite and neuronal cell growth [2]
- Advanced Biomechanical Properties: Non-linear elasticity and soft compliance for improved cell migration, growth, and differentiation
- High Biocompatibility: Minimizes adverse cellular responses
- Customizable Cell Culture Conditions: Easier optimization for specific research needs
- Safe & Reliable: Non-carcinogenic with low toxicity and immunogenicity
For research use only. Not intended for clinical or therapeutic use.
Fibrinogen & Thrombin Applications
- Fibrinogen Polymerization: Optimizes polymerization of salmon fibrinogen; additional growth benefits provided with the inclusion of fibronectin
- 3D Cell Culture: Supports non-mammalian ECM and fibrin hydrogel applications. Read our technical summary here.
- Tumor Cell Studies: Ideal for tumorigenic cell selection and growth [3]
- Stem Cell Research: Promotes selection and proliferation [6]
- Regenerative Medicine: Supports tissue engineering and repair [1, 2, 4]
Ready to elevate your research? Contact us today to learn more about our products.
A Better Hydrogel for 3D Cell Culture
Read our technical summary here
Benefits of fish-based hydrogels:
- Enhanced the growth of certain cell types
- Exhibits longer stability
- Broader temperature range
- Reduced stiffness for sensitive cultures
Thrombin Formulation & Specifications
- Format: Lyophilized powder
- Unit of Sale: 250 IU or 1000 IU glass vial
- Protein Content: >2.0 mg/ml
- Endotoxin Level: <10.0 EU/ml
- Filtration: 0.2 μm filtered
- Customization: Available in custom unit sizes
Storage & Shelf Life
- Storage: Below -60°C
- Shelf Life: 3 years from manufacture
Fibrinogen Formulation & Specifications
- Format: Lyophilized powder; non-lyophilized, frozen liquid available upon request
- Unit of Sale: 100 mg glass vial
- Protein Content: >90% clottable protein, >20 mg/ml
- Rheology: Shear modulus (2% strain, 1 Hz, 1200 sec) >1000 Pa
- Endotoxin Level: <10.0 EU/ml
- Customization: Available in custom unit sizes and non-lyophilized preparations
Storage & Shelf Life:
- Storage: Lyophilized powder -20°C (optimal) or 4-8°C; Frozen liquid ≤ -60°C
- Shelf Life: 3 years from manufacture
References
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Arulmoli J, Wright HJ, Phan DTT, Sheth U, Que RA, Botten GA, et al. (2017) Combination scaffolds of salmon fibrin, hyaluronic acid, and laminin for human neural stem cell and vascular tissue engineering. Acta Biomater. 43: 122-138.
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Ju YE, Janmey PA, McCormick ME, Sawyer ES, Flanagan LA (2007) Enhanced neurite growth from mammalian neurons in three-dimensional salmon fibrin gels. Biomaterials 28: 2097-2108.
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Liu J, Tan Y, Zhang H, Zhang Y, Xu P, Chen J, et al. (2012) Soft fibrin gels promote selection and growth of tumorigenic cells. Nature Mater 11: 734–741.
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Sharp KG, Dickson AR, Marchenko SA, Yee KM, Emery PN, Laidmae I, et al. (2012) Salmon fibrin treatment of spinal cord injury promotes functional recovery and density of serotonergic innervation. Exp Neurol 235(1): 345-356.
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Sieminski A & Gooch KJ (2004) Salmon fibrin supports an increased number of sprouts and decreased degradation while maintaining sprout length relative to human fibrin in an in vitro angiogenesis model. J Biomater Sci Polym Ed. 15(2): 237-42.
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Zhu P, Zhou Y, Wu F, Hong Y, Wang X, Shekhawat G, et al. (2017) Selective expansion of skeletal muscle stem cells from bulk muscle cells in soft three-dimensional fibrin gel. Stem Cells Translat Med 6:1412-1423.